Review Article

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

Table 1

Summary of a randomized clinical trial of CHM.

PrescriptionDesignSample sizeInterventionsMain outcomesReferences

Gushen Antai pillRCT83Treatment group: estradiol valerate + Gushen Antai pill1. Total efficiency: treatment group—84.85% (28/33); control group—68.00% (34/50)[29]
Control group: estradiol valerate2. Endometrial thickness after treatment: treatment group—0.73 ± 0.16 mm; control group—0.88 ± 0.18 mm

Bushen Huoxue recipeRCT60Treatment group: estradiol valerate + Bushen Huoxue recipe1. Pregnancy rate: treatment group—43.3% (13/30); control group—26.7 (8/30)[30]
Control group: estradiol valerate2. Endometrial thickness after treatment: treatment group—9.6 ± 1.0 mm; control group—8.2 ± 0.4 mm

Bushen Yanggong decoctionRCT120Treatment group: Femoston + Bushen Yanggong decoction1. Pregnancy rate: treatment group—53.33% (32/60); control group—31.67% (19/60)[31]
Control group: Femoston2. Endometrial thickness after treatment: treatment group—8.19 ± 0.83 mm; control group—7.17 ± 0.82 mm

Bubao decoctionRCT115Treatment group: Bubao decoction + aspirin enteric-coated aspirin group1. Clinical pregnancy rate: treatment group—47.62%; aspirin group—32.56%[34]
Control group2. Endometrial thickness after treatment: treatment group—10.65 ±3.03 mm; aspirin group—8.87 ± 2.50 mm

Danyu decoctionRCT50Treatment group: Danyu decoction1. Pregnancy rate: treatment group—60%; control group—28%[37]
Control group: vitamin E capsule2. The rate of type A endometrium: treatment group—84%; control group—68%
3. Treatment group: RI—0.55 ± 0.08; PI—1.83 ± 0.61; control group: RI—0.64 ± 0.16; PI—2.19 ± 0.54

Jieyuyubao pillsRCT107Treatment group: Jieyuyubao pills + clomiphene citrate1. Pregnancy rate: treatment group—24.07%; control group—11.32%[38]
2. The rate of type A endometrium: treatment group—53.7%; control group—35.8%
Control group: clomiphene citrate3. Symptom scores: treatment group—2.1 ± 0.6; control group—5.1 ± 0.6

Erzhi Tiangui granuleRCT66Treatment group: Erzhi Tiangui granule + gonadotropin therapy1. Clinical pregnancy rate: treatment group—54.55% (18/33); control group: 30.30% (10/33)[39]
Control group: gonadotropin therapy + placebo granules2. Endometrial DNMT1 expression: treatment group—3.31 ± 0.46; control group—2.97 ± 0.49

Yulin Zhuyun prescriptionRCT150Combine group: Yulin Zhuyun prescription + clomifene citrate capsules1. Clinical pregnancy rate: combine group—59.1% (26/44); CHM group—44.2% (19/43); Western medicine group—26.8% (11/41)[40]
CHM group: Yulin Zhuyun prescription2. Integrin αvβ3: combine group—13.1 ± 2.67; CHM group—13.82 ± 2.04; Western medicine group—7.05 ± 1.37
Western medicine group: Clomifene citrate capsules3. GLUT4: combine group—146.82 ± 21.84; CHM group—113.64 ± 15.62; Western medicine group—112.92 ± 18.54

Kuntai capsuleRCT71Treatment group: Kuntai capsule + clomiphene1. Pregnancy rate: treatment group—25% (9/36); control group—11.4% (4/35)[41]
Control group: placebo + clomiphene2. Integrin β3: treatment group—1.78 ± 0.226; control group—1.46 ± 0.252

Wenjing Quyu prescriptionRCT72Treatment group: Wenjing Quyu prescription + Gn + HCG1. Pregnancy rate: treatment group—59.38% (19/32); control group—12.96% (7/24)[45]
Control group: Gn + HCG2. Covered pinopode area: treatment group—>50%; control group—<20%

Huayu Xiaozheng prescriptionRCT60Treatment group: Huayu Xiaozheng prescription + urofollicle-stimulating hormone + chorionic gonadotropin + letrozole1. Pregnancy rate: treatment group—60% (18/30); control group—33.33% (10/30)[52]
Control group: urofollicle-stimulating hormone + chorionic gonadotropin + letrozole2. Uterine volume: treatment group—100.27 ± 2.13 cm3; control group—102.47 ± 3.90 cm3
3. Endometrial thickness after treatment: treatment group—9.89 ± 044 mm; control group—8.04 ± 1.28 mm

Yishen Sanjie Quyu decoctionRCT102Treatment group: Yishen Sanjie Quyu decoction1. Uterine volume: treatment group—95.46 ± 3.21 cm3; control group—105.44 ± 4.23 cm3[54]
Control group: Sanjie Zhentong capsule2. Symptom scores: treatment group—5.34 ± 1.46; control group—11.21 ± 2.01

Wenjing Yangxue decoctionRCT70Treatment group: Wenjing Yangxue decoction + dydrogesterone tablets + moxibustion1. Uterine volume: treatment group—136.47 ± 23.71 cm3; control group—152.38 ± 39.67 cm3[55]
Control group: dydrogesterone tablets + moxibustion2. RI : treatment group—0.63 ± 0.07; control group—0.66 ± 0.05

Penning granulesRCT58Treatment group: Penning granules1. Pregnancy rate: treatment group—54.55% (18/33); control group—20% (1/25)[58]
Control group: levofloxacin + metronidazole tablets2. CD38 : treatment group—8.89 ± 7.45; control group—20.12 ± 12.35
3. HIF-1α : treatment group—1.44 ± 0.95; control group—2.55 ± 1.40