Nobiletin Inhibits Non-Small-Cell Lung Cancer by Inactivating WNT/β-Catenin Signaling through Downregulating miR-15-5p

Figure 6

Nobiletin inhibits WNT/β-catenin signaling by inhibiting miR-15-5p. (a, b) The negative regulation of β-catenin expression by miR-15-5p was measured by western blot. (c) Western blot showing that miR-15-5p overexpression blocked nobiletin-induced inhibition of β-catenin expression in A549 cells. (d) A schematic model of the regulation of NSCLC progression by nobiletin.