Nobiletin Inhibits Non-Small-Cell Lung Cancer by Inactivating WNT/<i>β</i>-Catenin Signaling through Downregulating miR-15-5p

<div>Nobiletin significantly affected WNT/<i>β</i>-catenin signaling in NSCLC. (a) Heatmap showing that nobiletin treatment caused alterations in the expression levels of many genes in A594 and H460 cells. (b) Kyoto Encyclopedia of Gene and Genomes (KEGG) analysis revealed that nobiletin treatment significantly affected cancer stemness maintenance-related WNT/<i>β</i>-catenin signaling. (c). GSEA showed that nobiletin treatment negatively correlated with epithelial-mesenchymal transition (EMT) and cancer stemness in NSCLC (d).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3: Nobiletin Inhibits Non-Small-Cell Lung Cancer by Inactivating WNT/<i>β</i>-Catenin Signaling through Downregulating miR-15-5p 

Evidence-Based Complementary and Alternative Medicine

Nobiletin Inhibits Non-Small-Cell Lung Cancer by Inactivating WNT/β-Catenin Signaling through Downregulating miR-15-5p

Figure 3