RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats

<div>RNA-seq proved that QSG improved heart function of HF rats by regulating mitochondrial function. (a) KEGG pathways enrichment analysis of DEGs compared with MODEL and QSG. (b) GO annotation enrichment analysis of DEGs compared with MODEL and QSG. (c) PPI protein interaction analysis and for differential genes. (d) OPLS-DA 3D diagram of sham operation group (sham), model group (model), and Qishen granule group (QSG). (e) Effects of QSG on the mRNA expressions of the significantly altered genes in MI rat heart tissues by qRT-PCR assay. 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Evidence-Based Complementary and Alternative Medicine

fig1

Figure 1

Figure 1: RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats 