Network Pharmacology-Based Study on the Mechanism of Gegen Qinlian Decoction against Colorectal Cancer

Table 3

Information of 20 target genes in the pharmacological network.

Gene	Full name	Log2FC	Adjusted P value	Aliases
PTGS2	Prostaglandin G/H synthase 2	1.7769	7.39E − 03	PGHS-2; COX-2; PHS-2; PGG/HS; hCox-2; GRIPGHS
OLR1	Oxidized low-density lipoprotein receptor 1	1.9948	4.17E − 03	LOX1; LOXIN; SLOX1; CLEC8A; SCARE1
NR3C2	Nuclear receptor subfamily 3 group C member 2	−1.5129	3.92E − 03	MR; MCR; MLR; NR3C2VIT
HSD3B2	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	−1.1592	8.47E − 03	HSDB; HSD3B; SDR11E2
TNFSF15	TNF superfamily member 15	1.0461	1.24E − 02	TL1; TL1A; VEGI; TNLG1B; VEGI192A
MMP1	Matrix metallopeptidase 1	3.2300	2.86E − 03	CLG; CLGN
AKR1C3	Aldo-keto reductase family 1 member C3	−1.2267	6.79E − 03	DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS
CA2	Carbonic anhydrase 2	−1.7184	9.85E − 03	CAC; CAII; Car2; CAII; HEL-76; HEL-S-282
MMP3	Matrix metallopeptidase 3	4.1101	1.41E − 03	SL-1; STMY; STR1; CHDS6; MMP3; STMY1
PLAU	Plasminogen activator, urokinase	1.2642	4.83E − 03	ATF; QPD; UPA; URK; u-PA; BDPLT5
MMP9	Matrix metallopeptidase 9	1.1245	8.08E − 03	GELB; CLG4B; MMP9; MANDP2
IL1B	Interleukin 1 beta	2.1239	2.27E − 03	IL-1; IL1F2; IL1beta; IL1-BETA
DUOX2	Dual oxidase 2	1.9328	2.98E − 02	TDH6; LNOX2; THOX2; NOXEF2; P138-TOX
CCNB1	Cyclin B1	1.0204	1.50E − 02	CCNB
ABCG2	ATP binding cassette subfamily G member 2	−2.9521	2.92E − 03	MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; UAQTL1; EST157481
CXCL11	C-X-C motif chemokine ligand 11	3.4122	2.12E − 03	IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
CXCL10	C-X-C motif chemokine ligand 10	2.1322	6.06E − 03	C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
SPP1	Secreted phosphoprotein 1	1.5076	7.22E − 03	OPN; BNSP; BSPI; ETA-1
ADH1C	Alcohol dehydrogenase 1C (class I), gamma polypeptide	−2.9047	7.54E − 03	ADH3
MAOA	Monoamine oxidase A	−1.1045	7.88E − 03	BRNRS; MAO-a

FC, fold change.