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Author | Year | Country | Condition | Arms | Population | NPDS | Formulation | Control group | Evaluation criteria | Therapeutic efficacy |
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Shi et al. [25] | 2008 | China | Gout | 4 | 107 | Modified prescriptions of simiao pill | Pill | Indomethacin and benzbromarone | Guiding principle of clinical research on new drugs of traditional Chinese medicine | Joint arthralgia, erythema, and swelling, blood uric acid and gout recurrence↓ |
Renbin et al. [26] | 2008 | China | Gouty arthritis | 2 | 120 | Modified simiao tang | Decoction | Allopurinol tablet | An assemblage of guiding principles of clinical and preclinical research on new drugs | The index of swelling and pain in the joints, BUA, and CRP ↓ |
Song et al. [24] | 2008 | China | Gout | 2 | 200 | Weicao capsule | Capsule | Tong Feng Ding capsule | Diagnosis and curative effect standard of traditional Chinese medicine disease | Joint swelling and pain, laboratory indices↓ |
Zhang et al. [23] | 2010 | China | Acute gouty arthritis | 2 | 67 | Blood-letting cupping plus herbal medicine | Decoction | Diclofenac sodium enteric-coated tablets | The Budzyuski index of pain | Joint pain and swelling, BUA↓ |
Dalbeth et al. [28] | 2012 | New Zealand | Gout | 3 | 120 | SMP/GMP/G600 | Powder | GMP, G600 | The 10-point Likert scale | Gout flare, the severity of joint pain↓ |
Wang et al. [22] | 2014 | China | Acute gouty arthritis | 2 | 176 | Chuanhu antigout mixture | Decoction | Colchicine | — | Gout recurrence, CRP, AEs↓ |
Xie et al. [21] | 2017 | China | Intercritical and chronic gout | 2 | 210 | Compound tufuling oral liquid | Decoction | Placebo solution | — | The frequency of recurrent joint swelling and pain, BUA↓ |
Yu et al. [20] | 2018 | China | Gout with hyperuricemia | 3 | 72 | Yellow-dragon Wonderful-seed Formula | Decoction | Allopurinol group | SF-36 | Joint pain, BUA, and CRP↓ |
Singh et al. [27] | 2019 | USA | Gout | 2 | 84 | Cherry extract | Capsule | Diet modification | — | Joint pain intensity↓, average pain in last 24 h↓ |
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