Antimalarial Activities of Hydromethanolic Crude Extract and Chloroform Fraction of Gardenia ternifolia Leaves in Plasmodium berghei Infected Mice
Table 3
Mean percent parasitaemia and mean percent parasitemia inhibition of P. berghei-infected mice treated with hydromethanolic crude extract and chloroform fraction of G. ternifolia leaves in the Rane’s test.
Extract
Day 3 % parasitemia
Day-4 % parasitemia
Day 5
Day 6 % parasitemia
Day 7 % parasitemia
% parasitemia
% para. inhibition
CON 10 ml/kg
14.10 ± 0.54
35.00 ± 0.56
43.00 ± 1.58
0
0
0
CM 100 mg/kg
15.00 ± 0.37
34.00 ± 0.83
32.00 ± 0.45
25.58acde (3)
25.03 ± 0.59
21.00 ± 0.48
CM 200 mg/kg
14.03 ± 0.60
27.03 ± 0.81
27.10 ± 0.40
36.98 abe (3)
21.00 ± 0.46
17.05 ± 0.34
CM 400 mg/kg
15.10 ± 0.18
26.07 ± 0.46
22.03 ± 0.22
48.76 abe (3)
19.00 ± 0.60
14.03 ± 0.23
CF 100 mg/kg
12.13 ± 0.20
29.00 ± 0.30
23.07 ± 0.33
46.36 ade (3) c1
21.00 ± 0.37
16.90 ± 0.23
CF 200 mg/kg
14.05 ± 0.31
25.00 ± 0.24
15.97 ± 0.32
62.87 ade (3) b1
11.10 ± 0.16
10.03 ± 0.35
CF 400 mg/kg
15.13 ± 0.53
20.00 ± 0.52
11.00 ± 0.47
74.42 abce (3)
9.00 ± 0.16
7.17 ± 0.26
CQ 10 mg/kg
13.10 ± 0.38
7.07 ± 0.14
3.07 ± 0.22
92.87 abcd (3)
0.00 ± 0.00
0.00 ± 0.00
Data are expressed as mean ± SEM; (n = 6: CQ = chloroquine, CON = control, CM, crude hydromethanolic extract, CF = chloroform fraction of Gardenia ternifolia, % par supp = % parasitemia suppression). a, compared to negative control; b, compared to100 mg/kg; c, compared to 200 mg/kg; d, compared to 400 mg/kg; e, compared to CQ10 mg/kg: ,.
