Different Intensity Exercise Preconditions Affect Cardiac Function of Exhausted Rats through Regulating TXNIP/TRX/NF-ĸB_p65/NLRP3 Inflammatory Pathways

Table 1

The effect of EP with different intensity on cardiac function parameters in exhausted rats (, CON and HEP + EE, n = 10; EE, LEP + EE, and MEP + EE, n = 8).

	CON	EE	LEP + EE	MEP + EE	HEP + EE
Parameter
CO (ml/min)	31.33 ± 6.89	62.78 ± 9.60	44.78 ± 6.87^#	38.09 ± 9.54^#	61.01 ± 12.78
SV (µL)	96.69 ± 15.73	188.34 ± 39.33	105.97 ± 25.16^#	99.17 ± 19.96^#	117.17 ± 17.43^#
Ves (µL)	152.29 ± 23.86	235.97 ± 65.06	147.59 ± 69.20^#	107.79 ± 35.70^#	152.23 ± 28.17^#
Ved (μL)	220.48 ± 31.69	430.26 ± 88.97	236.35 ± 65.06^#	226.61 ± 32.06^#	262.66 ± 35.37^#
Pes (mmHg)	111.79 ± 18.47	115.43 ± 27.70	109.72 ± 21.43	137.79 ± 18.62^#▲	133.38 ± 20.69
Pdev (mmHg)	111.03 ± 18.73	96.44 ± 20.59	111.99 ± 19.13	139.81 ± 20.24^#▲	135.41 ± 16.53^#▲
HR (bpm)	320.41 ± 28.94	298.28 ± 58.59	344.33 ± 83.40	396.24 ± 12.65^#▲	397.67 ± 23.54^#▲
Systolic indices
EF (%)	44.24 ± 8.80	40.07 ± 8.12	56.74 ± 15.98^#	61.25 ± 8.74^#	58.15 ± 7.33^#
dP/dtmax (mmHg/s)	11025 ± 4472	7894 ± 2803	9518 ± 3299	13935 ± 2696^#▲	13171 ± 2350^#▲
ESPVR	0.81 ± 0.39	0.28 ± 0.12	0.73 ± 0.31^#	0.78 ± 0.29^#	1.03 ± 0.22^#▲
Diastolic indices
−dP/dtmin (mmHg/s)	−10718 ± 5866	−8346 ± 3093	−8985 ± 3987	−14068 ± 3221^#▲	−11589 ± 2889
Tau (ms)	4.76 ± 5.10	11.03 ± 2.46	11.47 ± 3.37	8.34 ± 1.07	9.71 ± 1.85

CON: the control group (n = 10), EE: the exhaustive exercise group (n = 8), LEP + EE: the low-intensity exercise Epreconditioning + exhaustive exercise group (n = 8), MEP + EE: the middle-intensity exercise preconditioning + exhaustive exercise group (n = 8), HEP + EE: the group intense exercise preconditioning + exhaustive exercise group (n = 10). CO: cardiac output; SV: stroke volume; Ves: end-systolic volume; Ved: end-diastolic volume; Pes: end-systolic pressure; Pdev: left ventricular development pressure; HR: heart rate; EF: ejection fraction; dP/dt_max: peak rate of the increase in pressure; ESPVR: slope of end-systolic pressure volume relationship; –dP/dt_min: peak rate of the decrease in pressure; Tau: relaxation time constant; , compared with the CON group; , compared with the EE group; , compared with the LEP + EE group; , compared with the MEP + EE group.