Antidiarrheal Activity of Hydromethanolic Root Extract and Solvent Fractions of Clutia abyssinica Jaub. & Spach. (Euphorbiaceae) in Mice

Table 4

In vivo antidiarrheal indices of root extract and fractions of C. abyssinica.

Treatments given		Dfreq (%)	Gmeq (%)	Pfreq (%)	ADI (%)
Extract (mg/kg)	100	82.88	17.22	32.32	35.86
	200	104.40	24.24	53.83	51.45
	400	119.44	52.41	67.80	75.15
Solvent fractions (mg/kg)	CF 100	22.92	18.74	27.70	22.83
	CF 200	47.46	39.10	39.98	42.02
	CF 400	150.00	44.96	63.02	75.19
	n-BF 100	15.74	23.32	33.80	23.15
	n-BF 200	21.53	33.25	41.55	30.98
	n-BF 400	65.74	36.08	61.50	52.64
	AF 100	26.39	30.81	47.65	33.84
	AF 200	41.67	35.52	58.45	44.23
	AF 400	67.36	46.89	66.11	59.33
Positive control		176.39	57.19	80.95	93.47

CF = chloroform fraction; n-BF = n-butanol fraction; AF = aqueous fraction; Dfreq = the delay in defecation time as a percentage of negative control; Gmeq = the gut meal travel reduction as a percentage of negative control; Pfreq = the reduction in purging frequency in the number of wet stools as a percentage of negative control; ADI = antidiarrheal index.