Antidiarrheal Activity of Hydromethanolic Root Extract and Solvent Fractions of Clutia abyssinica Jaub. & Spach. (Euphorbiaceae) in Mice

Table 3

The effect of root extract and fractions of C. abyssinica on intestinal transit in mice.

Treatment given		Length of the small intestine (cm)	Distance moved by charcoal meal (cm)	Peristaltic index	% inhibition
Negative control		60.00 ± 1.53	49.17 ± 1.96	81.90 ± 2.09	—
Extract (mg/kg)	100	61.50 ± 1.57	41.50 ± 2.46^d^e	67.80 ± 4.88^d^e	17.22
	200	60.83 ± 1.45	37.67 ± 3.92^d^e	62.05 ± 6.77^e	24.24
	400	61.17 ± 1.49	23.67 ± 1.38^a^b	38.98 ± 2.97^a^b	52.41
Solvent fractions (mg/kg)	CF 100	54.33 ± 2.01	35.83 ± 1.99^e	66.55 ± 4.91^d^e	18.74
	CF 200	51.17 ± 1.01	25.33 ± 4.10^a^b	49.88 ± 9.86^a	39.10
	CF 400	60.33 ± 1.41	27.00 ± 2.98^a^b	45.08 ± 5.49^a	44.96
	n-BF 100	57.83 ± 1.82	36.00 ± 3.09^e	61.98 ± 4.39^e	24.32
	n-BF 200	57.00 ± 2.44	31.00 ± 2.37^a	54.67 ± 4.03^a	33.25
	n-BF 400	58.67 ± 1.33	30.67 ± 3.02^a	52.35 ± 5.02^a	36.08
	AF 100	54.00 ± 2.31	30.33 ± 3.60^a	56.67 ± 6.67^a	30.81
	AF 200	55.83 ± 2.27	29.50 ± 2.75^a	52.82 ± 4.25^a	35.52
	AF 400	53.67 ± 2.75	23.17 ± 1.05^a^b	43.50 ± 2.09^a	46.89
Positive control		60.83 ± 1.35	21.33 ± 1.67^a^b	35.07 ± 2.52^a^b	57.19

CF = chloroform fraction; n-BF = n-butanol fraction; AF = aqueous fraction. Values are expressed as mean ± standard error of mean (); analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. ^acompared to negative control, ^bcompared to 100 mg/kg crude extract, ^ccompared to 200 mg/kg crude extract, ^dcompared to 400 mg/kg crude extract, ^ecompared to positive control. ; ; .