Antidiarrheal Activity of Hydromethanolic Root Extract and Solvent Fractions of Clutia abyssinica Jaub. & Spach. (Euphorbiaceae) in Mice

Table 2

Antienteropooling effects of C. abyssinica extract and solvent fractions.

Treatment given		VSIC (ml)	% inhibition in volume	WSIC (g)	% inhibition in weight
Negative control		0.86 ± 0.03	—	0.91 ± 0.03	—
Extract (mg/kg)	100	0.74 ± 0.03^e	14.48	0.80 ± 0.03^e	11.56
	200	0.62 ± 0.03^e	28.18	0.73 ± 0.02^e	19.44
	400	0.47 ± 0.02^a	45.74	0.50 ± 0.02^a	45.42
Solvent fractions (mg/kg)	CF 100	0.68 ± 0.05^e	10.23	0.78 ± 0.09^e	25.50
	CF 200	0.47 ± 0.33^a	25.09	0.65 ± 0.05	48.44
	CF 400	0.39 ± 0.04^a^b	47.68	0.45 ± 0.121^a	56.88
	n-BF 100	0.67 ± 0.06^e	20.65	0.69 ± 0.13	26.60
	n-BF 200	0.43 ± 0.03^a^b	50.39	0.49 ± 0.03^a	45.87
	n-BF 400	0.35 ± 0.08^a^b	51.73	0.42 ± 0.09^a	61.47
	AF 100	0.55 ± 0.08^a^e	33.20	0.58 ± 0.12	39.45
	AF 200	0.50 ± 0.12^a	41.70	0.51 ± 0.10	44.40
	AF 400	0.33 ± 0.10^a^b	43.24	0.49 ± 0.09^a	63.86
Positive control		0.20 ± 0.07^a^b	65.25	0.30 ± 0.11^a^b	77.98

Values are expressed as mean ± SEM (); analysis was performed using one-way ANOVA followed by Tukey’s post hoc test; ^acompared to negative control, ^bcompared to 100 mg/kg crude extract, ^ccompared to 200 mg/kg crude extract, ^dcompared to 400 mg/kg crude extract, ^ecompared to positive control. ; ; . CF = chloroform fraction; n-BF = n-butanol fraction; AF = aqueous fraction; VSIC = volume of small intestinal content; WSIC = weight of small intestinal content.