Optimization of Extraction Conditions of Phytochemical Compounds and Anti-Gout Activity of Euphorbia hirta L. (Ara Tanah) Using Response Surface Methodology and Liquid Chromatography-Mass Spectrometry (LC-MS) Analysis

Figure 2

Response surface plots of E. hirta showing the effect of (a) extraction time and extraction temperature, (b) solid-to-liquid ratio and extraction time, and (c) solid-to-liquid ratio and extraction temperature on total phenolic contents. Color gradients indicate the level of optimization (red = high, green = intermediate, and blue = low).

(a)

(b)

(c)