Acupuncture Therapy plus Hyaluronic Acid Injection for Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials

Table 2

The quality of evidence.

Outcomes	Effect		Number of participants (studies)	Quality of the evidence (GRADE)
	Relative effect (95% CI)	Absolute effect (95% CI)
LKSS	—	MD 8.67 higher (6.59 to 10.75 higher)	744 (7 studies)	⊕⊕⊝⊝ low^1,3
VAS	—	MD 1.39 lower (1.99 to 0.79 lower)	670 (7 studies)	⊕⊝⊝⊝ very low^1,2,3
ER	RR 1.23 (1.15 to 1.31)	173 more per 1000 (from 113 more to 233 more)	750 (8 studies)	⊕⊕⊝⊝ low^1,2

¹High risk of performance bias; one of the studies describe the allocation concealment. ²Adverse events were not sufficiently reported. ³Significant heterogeneity.