Revealing the Pharmacological Mechanism of Acorus tatarinowii in the Treatment of Ischemic Stroke Based on Network Pharmacology

Table 3

Potential targets related to IS and AT.

No.	Gene name	Protein name	UniProt ID	Degree
1	IL6	Interleukin-6	P05231	46
2	TNF	TNF-alpha	P01375	42
3	MAPK1	MAP kinase ERK2	P28482	41
4	PTGS2	Cyclooxygenase-2	P35354	40
5	IL1B	Interleukin-1 beta	P01584	39
6	VEGFA	Vascular endothelial growth factor A	P15692	39
7	JUN	Proto-oncogene c-JUN	P05412	34
8	TLR4	Toll-like receptor 4	O00206	33
9	MMP9	Matrix metalloproteinase 9	P14780	31
10	NOS3	Nitric-oxide synthase, endothelial	P29474	31
11	MAPK14	MAP kinase p38 alpha	Q16539	30
12	MPO	Myeloperoxidase	P05164	27
13	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	27
14	SERPINE1	Plasminogen activator inhibitor-1	P05121	25
15	MMP2	Matrix metalloproteinase 2	P08253	23
16	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	23
17	HMOX1	HMOX1	P09601	23
18	KDR	Vascular endothelial growth factor receptor 2	P35968	23
19	MMP1	Matrix metalloproteinase 1	P03956	20
20	NOS2	Nitric oxide synthase, inducible	P35228	20
21	MMP3	Matrix metalloproteinase 3	P08254	19
22	PTGS1	Cyclooxygenase-1	P23219	18
23	PLA2G1B	Phospholipase A2 group 1B	P04054	18
24	F3	Coagulation factor VII/tissue factor	P13726	18
25	F2	Thrombin	P00734	18
26	PLA2G4A	Cytosolic phospholipase A2	P47712	16
27	PTGES	Prostaglandin E synthase	O14684	16
28	IGF1R	Insulin-like growth factor I receptor	P08069	16
29	NFE2L2	Nuclear factor erythroid 2-related factor 2	Q16236	16
30	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	15
31	PLAT	Tissue-type plasminogen activator	P00750	15
32	TLR7	Toll-like receptor (TLR7/TLR9)	Q9NYK1	14
33	NR3C1	Glucocorticoid receptor	P04150	14
34	F2R	Proteinase-activated receptor 1	P25116	14
35	PLA2G2A	Phospholipase A2 group IIA	P14555	13
36	NQO1	Quinone reductase 1	P15559	13
37	PIK3CA	PI3-Kinase p110-alpha subunit	P42336	13
38	PARP1	Poly[ADP-ribose]polymerase-1	P09874	11
39	NAMPT	Nicotinamide phosphoribosyltransferase	P43490	11
40	ESR2	Estrogen receptor beta	Q92731	10
41	SHH	Sonic hedgehog protein (by homology)	Q15465	9
42	PLA2G6	Calcium-independent phospholipase A2	O60733	9
43	RAC1	Ras-related C3 botulinum toxin substrate 1	P63000	9
44	FABP4	Fatty acid binding protein adipocyte	P15090	9
45	VDR	Vitamin D receptor	P11473	8
46	LTA4H	Leukotriene A4 hydrolase	P09960	8
47	TBXAS1	Thromboxane-A synthase	P24557	8
48	PLA2G7	LDL-associated phospholipase A2	Q13093	8
49	P2RX7	P2X purinoceptor 7	Q99572	7
50	PIK3CG	PI3-Kinase p110-gamma subunit	P48736	7
51	FABP1	Fatty acid-binding protein, liver (by homology)	P07148	7
52	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	6
53	ITGAL	Leukocyte adhesion glycoprotein LFA-1 alpha	P20701	6
54	ODC1	Ornithine decarboxylase	P11926	5
55	PSEN1	Presenilin-1 (PS-1) (EC 3.4.23.-) (protein S182) [cleaved into presenilin-1 NTF subunit; presenilin-1 CTF subunit; presenilin-1 CTF12 (PS1-CTF12)]	P49768	4
56	NR3C2	Mineralocorticoid receptor	P08235	4
57	FADS1	Fatty acid desaturase 1	O60427	3
58	HDAC9	Histone deacetylase 9	Q9UKV0	2
59	PRKCH	Protein kinase C eta	P24723	2
60	LIMK1	LIM domain kinase 1	P53667	2
61	PDE4D	Phosphodiesterase 4D	Q08499	1
62	KCNQ1	Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK)	P51787	1