Tu-Teng-Cao Extract Alleviates Monosodium Urate-Induced Acute Gouty Arthritis in Rats by Inhibiting Uric Acid and Inflammation
Table 1
Effects of TTC on the volume of ankle joints in rats with acute gouty arthritis.
Group
Dose
Unit
Before injection of MSU
After injection of MSU
12 h
24 h
48 h
72 h
96 h
Normal
—
mm3
323.95 ± 23.48
324.18 ± 23.70
324.02 ± 23.39
325.07 ± 23.46
325.64 ± 23.50
327.02 ± 23.03
Model
—
mm3
317.59 ± 22.49
707.45 ± 102.95##
922.78 ± 121.11##
746.59 ± 130.50##
489.88 ± 79.71##
428.44 ± 74.84##
Colchicine
0.3 mg/kg
mm3
320.42 ± 23.83
635.78 ± 126.16
788.64 ± 119.54
564.06 ± 66.87
420.93 ± 54.30
376.24 ± 45.33
TTC-H
1 g/kg
mm3
318.56 ± 28.88
702.25 ± 89.91
864.86 ± 91.61
665.73 ± 88.41
446.62 ± 72.97
395.95 ± 74.66
TTC-M
0.5 g/kg
mm3
314.06 ± 24.93
646.97 ± 102.36
809.73 ± 141.09
625.73 ± 116.46
426.27 ± 79.66
385.67 ± 70.19
TTC-L
0.25 g/kg
mm3
319.05 ± 26.65
671.16 ± 122.82
817.61 ± 150.29
653.92 ± 164.91
504.37 ± 91.02
424.15 ± 83.42
Measurement data represent the mean ± standard deviation of 10 animals. One-way ANOVA followed by Student’s Newman–Keul’s test was used for statistical analysis. compared with the normal control group; compared with the model control group.