Tu-Teng-Cao Extract Alleviates Monosodium Urate-Induced Acute Gouty Arthritis in Rats by Inhibiting Uric Acid and Inflammation

Table 1

Effects of TTC on the volume of ankle joints in rats with acute gouty arthritis.

Group	Dose	Unit	Before injection of MSU	After injection of MSU
				12 h	24 h	48 h	72 h	96 h
Normal	—	mm^3	323.95 ± 23.48	324.18 ± 23.70	324.02 ± 23.39	325.07 ± 23.46	325.64 ± 23.50	327.02 ± 23.03
Model	—	mm^3	317.59 ± 22.49	707.45 ± 102.95^##	922.78 ± 121.11^##	746.59 ± 130.50^##	489.88 ± 79.71^##	428.44 ± 74.84^##
Colchicine	0.3 mg/kg	mm^3	320.42 ± 23.83	635.78 ± 126.16	788.64 ± 119.54	564.06 ± 66.87	420.93 ± 54.30	376.24 ± 45.33
TTC-H	1 g/kg	mm^3	318.56 ± 28.88	702.25 ± 89.91	864.86 ± 91.61	665.73 ± 88.41	446.62 ± 72.97	395.95 ± 74.66
TTC-M	0.5 g/kg	mm^3	314.06 ± 24.93	646.97 ± 102.36	809.73 ± 141.09	625.73 ± 116.46	426.27 ± 79.66	385.67 ± 70.19
TTC-L	0.25 g/kg	mm^3	319.05 ± 26.65	671.16 ± 122.82	817.61 ± 150.29	653.92 ± 164.91	504.37 ± 91.02	424.15 ± 83.42

Measurement data represent the mean ± standard deviation of 10 animals. One-way ANOVA followed by Student’s Newman–Keul’s test was used for statistical analysis. compared with the normal control group; compared with the model control group.