Tu-Teng-Cao Extract Alleviates Monosodium Urate-Induced Acute Gouty Arthritis in Rats by Inhibiting Uric Acid and Inflammation

Figure 5

Effect of TTC on MSU crystal-induced rat ankle joints and kidney lesions (n = 10). (A) Normal control group (injection of PBS). (B) Model control group (injection of MSU crystals). (C) Colchicine group. (D–F) TTC-H, TTC-M, and TTC-L (1, 0.5, and 0.25 g/kg, respectively) groups. (a) Cartilage: arrows indicating chondrocyte degeneration, and the nucleus disappears (B–C); enlargement of chondrocytes, and the nucleus becomes smaller or lysed (E–F). (b) Periosteum: arrows indicating thickening of synovia, myxedema, and increased number of cells (B–F). (c) Renal corpuscles: arrows indicating hypertrophy of glomerular mesangial cells, congestion in the glomeruli, and segmental increase in the number of parietal cells (B–F). (d) Convoluted tubules: arrows indicating swelling of renal tubules, shedding of endometrial cells, interstitial inflammation, stasis, and other lesions (B–F). Arrows indicating typical lesions; scale bar = 100 μm; original magnification ×400.

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