Research Article

Efficacy and Safety of Tanshinone for Chronic Kidney Disease: A Meta-Analysis

Table 1

Characteristics of included articles.

StudyYearTreatmentControlNumber (T/C)DurationResults report

Yang and Li [11]2016Sulfotanshinone IIA (40–80 mg/d, ivgtt, qd) + western standard treatmentWestern standard treatment96/9621 dmALB
Hu [12]2017Sulfotanshinone IIA (40 mg/d, ivgtt, qd) +  valsartan (80 mg/d, po, qd)Valsartan (80 mg/d, po, qd)40/4014 dScr
Ma et al. [9]2017Sulfotanshinone IIA (60 mg/d, ivgtt, qd) +  valsartan (80 mg/d, po, qd)Valsartan (80 mg/d, po, qd)36/3614 dScr
Li and Guo [13]2017Sulfotanshinone (60 mg/d, ivgtt, qd) +  valsartan (200 mg/d, po, qd)Valsartan (200 mg/d, po, qd)100/10014 dScr, CysC, 24-hour proteinuria
Cao et al. [14]2014Sulfotanshinone IIA (60 mg/d, ivgtt, qd) +  irbesartan (150 mg/d, po, qd)Irbesartan (150 mg/d, po, qd)45/4428 dmALB, 24-hour proteinuria
Tuxunguli [15]2017Sulfotanshinone IIA (60 mg/d, ivgtt, qd) +  valsartan (80 mg/d, po, qd)Valsartan (80 mg/d, po, qd)64/6414 dScr, CysC, 24-hour proteinuria
Li [16]2018Sulfotanshinone IIA (60 mg/d, ivgtt, qd) +  alprostadil (10 μg/d, iv, qd)Alprostadil (10 μg/d, iv, qd)52/5214 dBUN, scr, β2-MG
Gong et al. [17]2012Sulfotanshinone IIA (40 mg/d, ivgtt, qd) +  alprostadil (10 μg/d, iv, qd)Alprostadil (10 μg/d, iv, qd)39/3914 dBUN, β2-MG
Li [18]2007Sulfotanshinone IIA (60 mg/d, ivgtt, qd) +  western standard treatmentWestern standard treatment20/2021 dScr, safety
Gao and Gao [19]2011Sulfotanshinone IIA (50 mg/d, ivgtt, qd) +  western standard treatmentWestern standard treatment48/4228 dBUN, Scr,24-hour proteinuria
Yan et al. [20]2011Sulfotanshinone IIA (50 mg/d, ivgtt, qd) +  western standard treatmentWestern standard treatment71/5915 dGFR
Deng [21]2011Sulfotanshinone IIA (60 mg/d, ivgtt, qd) +  western standard treatmentWestern standard treatment20/2020 dCysC, 24-hour proteinuria
Wang [22]2014Sulfotanshinone IIA (40 mg/d, ivgtt, qd) +   + Alprostadil (10 μg/d, ivgtt, qd) +  western standard treatmentWestern standard treatment32/3228 dBUN, GFR, safety
Peng et al. [23]2010Sulfotanshinone IIA (40 mg/d, ivgtt, qd) +  haikun shenxi capsule (6 capsules/d, po, tid)Western standard treatment30/2821 dBUN, scr
Wei et al. [24]2016Sulfotanshinone IIA (40 mg/d, ivgtt, qd) +  alprostadil (10 μg/d, ivgtt, qd)Alprostadil (10 μg/d, ivgtt, qd)27/1514 dBUN
Xu [25]2013Sulfotanshinone IIA (50 mg/d, ivgtt, qd) +  alprostadil (10 μg/d, ivgtt, qd)Alprostadil (10 μg/d, ivgtt, qd)40/4028 dScr
Wang [26]2018Sulfotanshinone IIA (50 mg/d, ivgtt, qd) +  shen kang injection (100 ml/d, ivgtt, qd)Western standard treatment50/5030 d24-hour proteinuria
Ping [27]2007Sulfotanshinone IIA (50 mg/d, ivgtt, qd) +  prednisone (1 mg/kg/d, po, qd)Prednisone (1 mg/kg/d, po, qd)40/2221 dBUN
Chen et al. [28]2009Sulfotanshinone IIA (100 mg/d, ivgtt, qd) +  prednisone (1 mg/kg/d, po, qd)Prednisone (1 mg/kg/d, po, qd)60/6060 dBUN
Liao et al. [29]2009Sulfotanshinone IIA (0.5 mg/kg/d, ivgtt, qd) +  western standard treatmentWestern standard treatment14/147 dGFR
Gu et al. [30]2013Sulfotanshinone IIA (0.5 mg/kg/d, ivgtt, qd) +  western standard treatmentWestern standard treatment30/3014 dGFR