In Vitro Antiplasmodium and Chloroquine Resistance Reversal Effects of Andrographolide

Table 5

Results of the FIC₅₀- and FIC₉₀-based isobolograms for CQ/andrographolide mixtures.

Mixing ratio (CQ/andro)	FIC50-based isobologram					FIC90-based siobologram
	IC50 CQ in nM	IC50 andro in µM	FIC50 CQ	FIC50 andro	Total	IC90 CQ in nM	IC90 andro in µM	FIC90 CQ	FIC90 andro	Total
10/0	269.2 ± 0.4	0	1.00	0.00	1.00	791.51 ± 0.00	0	1.00	0.000	1.00
7/3	184.0 ± 5.4	0.32 ± 0.02	0.68	0.30	0.99	595.58 ± 42.48	1.31 ± 0.068	0.75	0.06	0.81
5/5	128.2 ± 9.7	0.51 ± 0.05	0.48	0.49	0.97	447.20 ± 36.41	2.62 ± 0.13	0.56	0.10	0.66
3/7	95.1 ± 9.2	0.91 ± 0.03	0.35	0.85	1.21	329.83 ± 39.90	4.7 ± 0.35	0.42	0.17	0.59
0/10	0.0 ± 0.00	1.08 ± 0.00	0.00	1.00	1.00	0.00 ± 0.00	26.4 ± 0.91	0.00	1.00	1.00