Aqueous and Methanol Extracts of Paullinia pinnata (Sapindaceae) Improve Monosodium Urate-Induced Gouty Arthritis in Rat: Analgesic, Anti-Inflammatory, and Antioxidant Effects

Figure 6

Effects of the aqueous (AEPP) and methanol (MEPP) extracts of Paullinia pinnata on the malondialdehyde (MDA) content in the spinal cord of MSU-injected animals. Allopurinol (5 mg/kg/day) is used as a positive control for antigouty effects. (a) AEPP treatment at 200 mg/kg and 300 mg/kg reversed MSU-induced increases in MDA spinal cord content (one-way ANOVA significant main effect ). (b) MEPP treatment at 100, 200, and 300 mg/kg reversed MSU-induced increase in MDA spinal cord content (one-way ANOVA significant main effect ). Each bar represents the mean ± SEM of 6 individual rats. ; significant difference compared to the negative control group (MSU + DMSO) using one-way ANOVA with Tukey’s posttest. , , ; significant difference compared to sham using one-way ANOVA with Tukey’s posttest.

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