Aqueous and Methanol Extracts of Paullinia pinnata (Sapindaceae) Improve Monosodium Urate-Induced Gouty Arthritis in Rat: Analgesic, Anti-Inflammatory, and Antioxidant Effects

Figure 3

Effects of the aqueous (AEPP) and methanol (MEPP) extracts of Paullinia pinnata on myeloperoxidase (MPO) activity in the synovial liquid of MSU-injected animals. Allopurinol (5 mg/kg/day) was used as a positive control. (a) AEPP treatment at 100 mg/kg and 200 mg/kg reversed MSU-induced increases in MPO activity in synovial liquid. (b) MEPP treatment at 100 and 200 mg/kg reversed MSU-induced increases in MPO activity in synovial liquid. Each bar represents the mean ± SEM of 6 individual rats. , ; significant difference compared to the negative control group (MSU + DMSO) using one-way ANOVA with Tukey’s posttest. significant difference compared to the sham group using one-way ANOVA with Tukey’s posttest.

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