Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherapeutic Efficacy, and Reduce Tumour Xenograft Growth In Vivo in Prostate Cancer
Figure 1
Dandelion root and lemongrass extracts induce apoptosis in prostate cancer cells. (a) Prostate cell line DU-145 was treated with various treatments of DRE, LGE, and chemotherapeutics taxol and mitoxantrone and assessed at 48 hours and 96 hours. Results were obtained using image-based cytometry to assess the percentage of live cells compared to a vehicle control. (b) Prostate cell lines DU-145 (top panels) and PC-3 (bottom panels) were treated with various treatments of DRE, LGE, and chemotherapeutics and assessed at 48 hours and 96 hours. Results were obtained using image-based cytometry to assess the percentage of cells positive with fluorescence associated with Annexin V (green), propidium iodide (PI, red), both (yellow), or negative for both Annexin V and PI (blue). Values are expressed as a mean ± SD from three independent experiments. Statistical calculations were performed using Two-Way ANOVA multiple comparison. p < 0.05 vs. control, p < 0.01 vs. control, p < 0.0001 vs. control.