Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice

Figure 3

Protective effect of GIN on the learning and memory deficits caused by SCO based on the passive avoidance and contextual fear conditioning tests. One hour before this test, the mice were treated with vehicle or GIN (10 or 25 mg/kg, p.o.), and 30 min later, they were treated with vehicle or SCO (1 mg/kg, i.p.). (a) Effect of GIN on the SCO-diminished step-through latency was monitored during the retention trial. (b) Effect of GIN on the SCO-decreased immovable time without any movement for the freezing response was examined. Data were presented as mean ± SEM (). Significant difference between the groups: , vehicle-treated control versus SCO group; , SCO alone group versus GIN-treated group in combination with SCO.

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