Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice

Figure 1

Memory enhancing effects of ginger extracts based on the Y-maze task. One hour before the test, the mice were treated with vehicle or ginger extracts (FGE, 100 or 200 mg/kg; DGE, 100 or 200 mg/kg; p.o.), and 30 min later, the mice were injected with vehicle or scopolamine (SCO, 1 mg/kg, i.p.). (a) Effects of ginger extracts on the SCO-induced spontaneous alternation. (b) Total number of arm entries drug during the 8-min trials of the Y-maze task. Data were presented as mean ± SEM (). Significant difference between the groups: , vehicle-treated control versus SCO group; , SCO group versus ginger extract-treated group in combination with SCO.

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