Pharmacological Effect of Caulophyllum robustum on Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-κB, and Proinflammatory Cytokines In Vivo and In Vitro

Figure 5

Effect of CRME on the secretion of proinflammatory mediators in CIA mice. The levels of TNF-α (a), IL-6 (b), IL-1β (c), and PGE2 (d) were monitored in the medium by using ELISA. Data represent the mean ± SD of three separate experiments. Data were analyzed by two-way ANOVA and Student-Newman-Keuls test as post hoc test (, compared with the normal group. and , compared with vehicle group. , , and , compared with MTX group. , , and , compared with Tri group).

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