Optimized-SopungSunkiwon, a Herbal Formula, Attenuates Aβ Oligomer-Induced Neurotoxicity in Alzheimer’s Disease Models

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2"></td><td class="align_center" colspan="2">IC50 (μg/mL)</td></tr><tr class="thead"><td class="align_center">DPPH assay</td><td class="align_center">ABTS assay</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">OSS</td><td class="align_center">18.33</td><td class="align_center">25.34</td></tr><tr><td class="align_left">SBE</td><td class="align_center">27.75</td><td class="align_center">25.40</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

IC50 values for DPPH and ABTS radical scavenging activity. OSS showed higher DPPH free radical and ABTS cation scavenging activity than that of positive control. Data were expressed as IC50 values. OSS: Optimized-SopungSunkiwon extract and SBE: Scutellaria baicalensis Georgi extract (used as a positive control).

Evidence-Based Complementary and Alternative Medicine

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Table 1

Table 1: Optimized-SopungSunkiwon, a Herbal Formula, Attenuates Aβ Oligomer-Induced Neurotoxicity in Alzheimer’s Disease Models