Optimized-SopungSunkiwon, a Herbal Formula, Attenuates Aβ Oligomer-Induced Neurotoxicity in Alzheimer’s Disease Models

Figure 7

Effect of OSS on -induced presynaptic and postsynaptic damage in the hippocampus. Mice were treated with vehicle or OSS for 14 days, starting from 5 days before stereotaxic injection of . The immunoreactivity of SYN (a) and PSD-95 (b) was quantified by measuring the density of each stained area in the hippocampal CA3 region, respectively. Representative photomicrographs are shown for the SYN (c–g) and PSD-95 (h–l) stained cells from each group (400x magnification). Scale bar = 50 μm. (c, h) Sham-operated group; (d, i) only treated group; (e, j) + OSS 50 mg/kg/day group; (f, k) + OSS 100 mg/kg/day group; (g, l) + OSS 200 mg/kg/day group. Data are expressed as percentages relative to sham-operated group. Values are indicated as the mean ± SEM. compared to sham-operated group; , , and compared to the -only treated group.

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