Optimized-SopungSunkiwon, a Herbal Formula, Attenuates Aβ Oligomer-Induced Neurotoxicity in Alzheimer’s Disease Models

Figure 5

Effect of OSS on hippocampal cell death induced by toxicity. Mice were treated with vehicle or OSS for 14 days, starting from 5 days before stereotaxic injection of . Hippocampal cell loss was determined using cresyl violet staining. Quantification was performed by measuring the cell intensity of stained cells in the GCL (a) and in the CA3 (b). Representative photomicrographs are shown for the GCL (c–g) and CA3 (h–l) from each group (400x magnification). Scale bar = 50 μm. (c, h) Sham-operated group; (d, i) only treated group; (e, j) + OSS 50 mg/kg/day group; (f, k) + OSS 100 mg/kg/day group; (g, l) + OSS 200 mg/kg/day group. Data are expressed as percentages relative to sham-operated group. Values are indicated as the mean ± SEM. and compared to sham-operated group; compared to the -only treated group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)