Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga Biome

Table 3

Inhibitory concentration of Caryocar coriaceum fruit extracts on promastigote forms of L. amazonensis (IC₅₀) after 24, 48, and 72 h of treatment, toxicity to peritoneal macrophages (CC₅₀), and selectivity index (SI) after 24 h of treatment. Values are expressed in μg/mL.

	24 h	CC50	SI	48 h	72 h
	IC50			IC50	IC50
Pulp extract	30 ± 5.0	253 ± 42.0	8.43	39 ± 8.0	17 ± 7.0
Peel extract	38 ± 13.0	454 ± 11.0	11.94	31 ± 9.0	22 ± 3.0
Pentamidine [9]	23.71; (18.44–30.50)	17.90; (0.02–0.03)	0.75
Glucantime [17]	13.95 (±2.06)

Data represent the mean ± SEM of at least three independent experiments performed in triplicate. CC₅₀: cytotoxic concentration of 50% of macrophages (µg/mL). IC₅₀: inhibitory concentration of 50% of promastigote forms (µg/mL). SI: selectivity index = CC₅₀/IC₅₀. Similar letters indicate significant similarities between rows ( ≤ 0.05, according to ANOVA followed by Tukey’s test).