TY - JOUR A2 - Quintans, Lucindo AU - Alves, Daniela Ribeiro AU - Maia de Morais, Selene AU - Tomiotto-Pellissier, Fernanda AU - Miranda-Sapla, Milena Menegazzo AU - Vasconcelos, Fábio Roger AU - Silva, Isaac Neto Goes da AU - Araujo de Sousa, Halisson AU - Assolini, João Paulo AU - Conchon-Costa, Ivete AU - Pavanelli, Wander Rogério AU - Freire, Francisco das Chagas Oliveira PY - 2017 DA - 2017/09/07 TI - Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga Biome SP - 6834218 VL - 2017 AB - Caryocar coriaceum fruits, found in Brazilian Cerrado and Caatinga, are commonly used as food and in folk medicine, as anti-inflammatory, bactericide, fungicide, leishmanicide, and nematicide. Due to the biological potential of this plant, this study focuses on the evaluation of antifungal and antileishmanial activities, including anticholinesterase and antioxidant tests, correlating with total phenols and flavonoids content. Peel extracts contain higher yield of phenols and flavonoids as analyzed by spectrophotometric methods. HPLC analysis of flavonoids revealed that isoquercitrin is the main flavonoid in both parts of the fruit, and peel extract showed the best antioxidant activity. In the inhibition of the acetylcholinesterase assay, both extracts demonstrate action comparable to physostigmine. The antimicrobial activity of extracts was evaluated against strains of Malassezia sp. and Microsporum canis, using the broth microdilution technique, in which the extracts showed similar MIC and MFC. The extracts present antileishmanial activity and low toxicity on murine macrophages and erythrocytes. Therefore, these results suggest a potential for the application of C. coriaceum fruit’s ethanol extracts in the treatment against dermatophyte fungi and leishmaniasis, probably due to the presence of active flavonoids. Further in vivo studies are recommended aiming at the development of possible new pharmaceutical compounds. SN - 1741-427X UR - https://doi.org/10.1155/2017/6834218 DO - 10.1155/2017/6834218 JF - Evidence-Based Complementary and Alternative Medicine PB - Hindawi KW - ER -