TY - JOUR
A2 - Quintans, Lucindo
AU - Alves, Daniela Ribeiro
AU - Maia de Morais, Selene
AU - Tomiotto-Pellissier, Fernanda
AU - Miranda-Sapla, Milena Menegazzo
AU - Vasconcelos, Fábio Roger
AU - Silva, Isaac Neto Goes da
AU - Araujo de Sousa, Halisson
AU - Assolini, João Paulo
AU - Conchon-Costa, Ivete
AU - Pavanelli, Wander Rogério
AU - Freire, Francisco das Chagas Oliveira
PY - 2017
DA - 2017/09/07
TI - Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga Biome
SP - 6834218
VL - 2017
AB - Caryocar coriaceum fruits, found in Brazilian Cerrado and Caatinga, are commonly used as food and in folk medicine, as anti-inflammatory, bactericide, fungicide, leishmanicide, and nematicide. Due to the biological potential of this plant, this study focuses on the evaluation of antifungal and antileishmanial activities, including anticholinesterase and antioxidant tests, correlating with total phenols and flavonoids content. Peel extracts contain higher yield of phenols and flavonoids as analyzed by spectrophotometric methods. HPLC analysis of flavonoids revealed that isoquercitrin is the main flavonoid in both parts of the fruit, and peel extract showed the best antioxidant activity. In the inhibition of the acetylcholinesterase assay, both extracts demonstrate action comparable to physostigmine. The antimicrobial activity of extracts was evaluated against strains of Malassezia sp. and Microsporum canis, using the broth microdilution technique, in which the extracts showed similar MIC and MFC. The extracts present antileishmanial activity and low toxicity on murine macrophages and erythrocytes. Therefore, these results suggest a potential for the application of C. coriaceum fruit’s ethanol extracts in the treatment against dermatophyte fungi and leishmaniasis, probably due to the presence of active flavonoids. Further in vivo studies are recommended aiming at the development of possible new pharmaceutical compounds.
SN - 1741-427X
UR - https://doi.org/10.1155/2017/6834218
DO - 10.1155/2017/6834218
JF - Evidence-Based Complementary and Alternative Medicine
PB - Hindawi
KW -
ER -