A Molecular Basis for the Inhibition of Transient Receptor Potential Vanilloid Type 1 by Gomisin A

Figure 4

The binding pocket and docking results of gomisin A and TRPV1 channel. (a) Gomisin A located in binding pocket in extracellular area between segments 1 and 2 of TRPV1 channel. (b) 2D schematic presentation of the predicted binding mode of gomisin A in the ligand binding pocket. The ligands and important residues are shown. (c and d) Binding interface and gomisin A of the wild type (c) and the four mutant channels, whose mutations disturb the interaction with gomisin A to varying degrees.

(a)

(b)

(c)

(d)