TY - JOUR
A2 - Hugel, Helmut
AU - Ozarowski, Marcin
AU - Mikolajczak, Przemyslaw L.
AU - Piasecka, Anna
AU - Kachlicki, Piotr
AU - Kujawski, Radoslaw
AU - Bogacz, Anna
AU - Bartkowiak-Wieczorek, Joanna
AU - Szulc, Michal
AU - Kaminska, Ewa
AU - Kujawska, Malgorzata
AU - Jodynis-Liebert, Jadwiga
AU - Gryszczynska, Agnieszka
AU - Opala, Bogna
AU - Lowicki, Zdzislaw
AU - Seremak-Mrozikiewicz, Agnieszka
AU - Czerny, Boguslaw
PY - 2016
DA - 2016/04/28
TI - Influence of the Melissa officinalis Leaf Extract on Long-Term Memory in Scopolamine Animal Model with Assessment of Mechanism of Action
SP - 9729818
VL - 2016
AB - Melissa officinalis (MO, English: lemon balm, Lamiaceae), one of the oldest and still most popular aromatic medicinal plants, is used in phytomedicine for the prevention and treatment of nervous disturbances. The aim of our study was to assess the effect of subchronic (28-fold) administration of a 50% ethanol extract of MO leaves (200 mg/kg, p.o.) compared with rosmarinic acid (RA, 10 mg/kg, p.o.) and huperzine A (HU, 0.5 mg/kg, p.o.) on behavioral and cognitive responses in scopolamine-induced rats. The results were linked with acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and beta-secretase (BACE-1) mRNA levels and AChE and BuChE activities in the hippocampus and frontal cortex of rats. In our study, MO and HU, but not RA, showed an improvement in long-term memory. The results were in line with mRNA levels, since MO produced a decrease of AChE mRNA level by 52% in the cortex and caused a strong significant inhibition of BACE1 mRNA transcription (64% in the frontal cortex; 50% in the hippocampus). However, the extract produced only an insignificant inhibition of AChE activity in the frontal cortex. The mechanisms of MO action are probably more complicated, since its role as a modulator of beta-secretase activity should be taken into consideration.
SN - 1741-427X
UR - https://doi.org/10.1155/2016/9729818
DO - 10.1155/2016/9729818
JF - Evidence-Based Complementary and Alternative Medicine
PB - Hindawi Publishing Corporation
KW -
ER -