Evidence-Based Complementary and Alternative Medicine

Research Article

ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula

Table 1

Sixteen bioactive components and their regulated TFs and DEGs.


TCM	TZS components	The CID of component that interacts with TF	Tanimoto coefficient	TF	Differential expression genes

Gastrodia elata BL.	4,4′-Dihydroxydiphenyl methane	6623	0.877023	ER-alpha	F5/Hba-a2/Rnase111
	β-Sitosterol	2371	0.915282	Sp1	Rnase4/F5/Slc19a3
	β-Sitosterol	2524	0.896709	Egr-1	Ifitm7
	Citric acid	311	1	Olf-1	Cyp2a2/Cyp2j4
	3-Hydroxy-3-methoxycarbonylpentanedioic acid	311	0.8	Olf-1	Cyp2a2/Cyp2j4
	Daucosterol	2371	0.879428	Sp1	Rnase4/F5/Slc19a3
	Daucosterol	2524	0.852015	Egr-1	Ifitm7
	Margaric acid	985	0.994764	Sp1	Rnase4/F5/Slc19a3
		2506	0.941581	Sp1	Rnase4/F5/Slc19a3
		148177	0.875424	Sp1	Rnase4/F5/Slc19a3
	Bis(4-Hydroxybenzyl)ether	6623	0.850932	ER-alpha	F5/Hba-a2/Rnasel11
	Vitamin A	5538	0.970093	c-Fos	Dusp12/Gpatch4/Ngf/Nts/Hba-a2/RGD1564469
	Vitamin A	1744	0.856672	CHOP-10	Ttr/Kcnj13
	Palmitic acid	985	1	Sp1	Rnase4/F5/Slc19a3
	Palmitic acid	2506	0.933009	Sp1	Rnase4/F5/Slc19a3
	Palmitoyl glycerol	2506	0.96445	Sp1	Rnase4/F5/Slc19a3
		985	0.94697	Sp1	Rnase4/F5/Slc19a3
		3987	0.916115	Egr-1	Ifitm7
		148177	0.884291	Sp1	Rnase4/F5/Slc19a3
		2499	0.852916	STAT5B	Clic6

Trillium tschonoskii Maxim.	Pennogenin	2524	0.890232	Egr-1	Ifitm7
		2371	0.882143	Sp1	Rnase4/F5/Slc19a3
		54454	0.863784	ATF-2	Cyp2j4/Rasl11a/Slc16a13
	Linoleic acid	1424	0.932432	RelA	Cyp2j4/RT1-T24-4/Nqo2
		3987	0.865169	Egr-1	Ifitm7
		1444	0.860317	STAT3	Clic6/Hbb/Krt18/Fpr-rs3/Ifitm7/RGD1564126/Zfp467
	4-Hydroxybenzoic acid	44540357	0.8679	c-Jun	Dusp12/Gpatch4/Ngf/Fpr-rs3/Hba-a2/RGD1564469/S100vp
	3-O--L-Rhamnopyranosyl (13) sterylglucoside	2371	0.879428	Sp1	Rnase4/F5/Slc19a3
	3-O--L-Rhamnopyranosyl (13) sterylglucoside	2524	0.852015	Egr-1	Ifitm7
	26-Chloro-26-deoxycryptogenin	2371	0.886708	Sp1	Rnase4/F5/Slc19a3
		2524	0.878365	Egr-1	Ifitm7
		146898	0.862239	STAT2	Clic6/Naip5/Cyp11b3
		54454	0.855305	ATF-2	Cyp2j4/Rasl11a/Slc16a13
		400769	0.853801	STAT3	Clic6/Hbb/Krt18/Fpr-rs3/Ifitm7/RGD1564126/Zfp467
		5753	0.853659	FOXO3	Fpr-rs3/RGD1559708
	Diosgenin	2371	0.885714	Sp1	Rnase4/F5/Slc19a3
		2524	0.881	Egr-1	Ifitm7
		54454	0.866091	ATF-2	Cyp2j4/Rasl11a/Slc16a13

The Tanimoto coefficient of these components was greater than 0.85; this table shows the corresponding relationship between the bioactive components, TFs and DEGs.