Uliginosin B, a Possible New Analgesic Drug, Acts by Modulating the Adenosinergic System

Figure 3

Effect of pretreatment with EHNA (5 mg/kg, i.p. (a)), dipyridamole (DIP: 30 mg/kg, i.p. (b)), or AMPCP (2 mg/kg, i.p. (c)), before treatment with uliginosin B (ULI: 15 mg/kg, i.p.) in the hot-plate test. Percentages of maximal possible analgesic effect (% MPE) are presented as means ± SEM (-10 mice/group). compared to vehicle group; compared to uliginosin B (15 mg/kg, i.p.) group (ANOVA followed by Student-Newman-Keuls). Data are presented in mean ± SEM ( mice/group). Significantly different values were detected by one-way ANOVA followed by Student-Newman-Keuls: compared to vehicle.

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