Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats

Figure 1

Pictomicrographs of the liver of NC (a) rats and insulin resistant male Wistar rats induced with high fat diet before (b) and after being treated with T. crispa (c) and orlistat (d) (H&E staining ×20). The HFD group (b) showed severe degrees of micro- and macrovesicular steatosis and severe hepatocellular ballooning while the rest ((a), (b), and (c)) showed normal hepatocytes with intact morphologies.

(a) Normal control (NC)

(b) High fat diet (HFD)

(c) High fat diet + T. crispa (HFDTC)

(d) High fat diet + orlistat (HFDO)