TY - JOUR A2 - Wang, Yi-tao AU - Chen, Lijuan AU - Yan, Xin AU - Yan, Qianlin AU - Fan, Jiajun AU - Huang, Hai AU - Shi, Xunlong AU - Han, Lei AU - Han, Tianxiong AU - Zhu, Haiyan PY - 2015 DA - 2015/05/18 TI - The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice SP - 790739 VL - 2015 AB - A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response. JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China. In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice. The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-α, IL-1, IL-6, MCP-1, RANTES, and IFN-α on day 4 after infection. Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries. The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-κB pathway. Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia. SN - 1741-427X UR - https://doi.org/10.1155/2015/790739 DO - 10.1155/2015/790739 JF - Evidence-Based Complementary and Alternative Medicine PB - Hindawi Publishing Corporation KW - ER -