TY - JOUR
A2 - Wang, Yi-tao
AU - Chen, Lijuan
AU - Yan, Xin
AU - Yan, Qianlin
AU - Fan, Jiajun
AU - Huang, Hai
AU - Shi, Xunlong
AU - Han, Lei
AU - Han, Tianxiong
AU - Zhu, Haiyan
PY - 2015
DA - 2015/05/18
TI - The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice
SP - 790739
VL - 2015
AB - A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response. JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China. In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice. The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-α, IL-1, IL-6, MCP-1, RANTES, and IFN-α on day 4 after infection. Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries. The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-κB pathway. Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia.
SN - 1741-427X
UR - https://doi.org/10.1155/2015/790739
DO - 10.1155/2015/790739
JF - Evidence-Based Complementary and Alternative Medicine
PB - Hindawi Publishing Corporation
KW -
ER -