TY - JOUR
A2 - Jadeja, Ravirajsinh N.
AU - Wu, Jia-Ping
AU - Tsai, Chin-Chuan
AU - Yeh, Yu-Lan
AU - Lin, Yueh-Min
AU - Lin, Chien-Chung
AU - Day, Cecilia Hsuan
AU - Shen, Chia-Yao
AU - Padma, V. Vijaya
AU - Pan, Lung-Fa
AU - Huang, Chih-Yang
PY - 2015
DA - 2015/08/03
TI - [Retracted] Silymarin Accelerates Liver Regeneration after Partial Hepatectomy
SP - 603529
VL - 2015
AB - Partial hepatectomy (PHx) is a liver regeneration physiological response induced to maintain homeostasis. Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury. Silymarin (Sm) ability to stimulate liver regeneration has been an object of curiosity for many years. Silymarin has been investigated for use as an antioxidant and anticarcinogen. However, its use as a supportive treatment for liver damage is elusive. In this study, we fed silymarin (Sm, 25 mg/kg) to male Sprague-Dawley rats for 7 weeks. Surgical 2/3 PHx was then conducted on the rats at 6 hrs, 24 hrs, and 72 hrs. Western blot and RT-PCR were conducted to detect the cell cycle activities and silymarin effects on hepatic regeneration. The results showed that silymarin enhanced liver regeneration by accelerating the cell cycle in PHx liver. Silymarin led to increased G1 phase (cyclin D1/pRb), S phase (cyclin E/E2F), G2 phase (cyclin B), and M phase (cyclin A) protein and mRNA at 6 hrs, 24 hrs, and 72 hrs PHx. HGF, TGFα, and TGFβ1 growth factor expressions were also enhanced. We suggest that silymarin plays a crucial role in accelerated liver regeneration after PHx.
SN - 1741-427X
UR - https://doi.org/10.1155/2015/603529
DO - 10.1155/2015/603529
JF - Evidence-Based Complementary and Alternative Medicine
PB - Hindawi Publishing Corporation
KW -
ER -