TY - JOUR A2 - Jadeja, Ravirajsinh N. AU - Wu, Jia-Ping AU - Tsai, Chin-Chuan AU - Yeh, Yu-Lan AU - Lin, Yueh-Min AU - Lin, Chien-Chung AU - Day, Cecilia Hsuan AU - Shen, Chia-Yao AU - Padma, V. Vijaya AU - Pan, Lung-Fa AU - Huang, Chih-Yang PY - 2015 DA - 2015/08/03 TI - [Retracted] Silymarin Accelerates Liver Regeneration after Partial Hepatectomy SP - 603529 VL - 2015 AB - Partial hepatectomy (PHx) is a liver regeneration physiological response induced to maintain homeostasis. Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury. Silymarin (Sm) ability to stimulate liver regeneration has been an object of curiosity for many years. Silymarin has been investigated for use as an antioxidant and anticarcinogen. However, its use as a supportive treatment for liver damage is elusive. In this study, we fed silymarin (Sm, 25 mg/kg) to male Sprague-Dawley rats for 7 weeks. Surgical 2/3 PHx was then conducted on the rats at 6 hrs, 24 hrs, and 72 hrs. Western blot and RT-PCR were conducted to detect the cell cycle activities and silymarin effects on hepatic regeneration. The results showed that silymarin enhanced liver regeneration by accelerating the cell cycle in PHx liver. Silymarin led to increased G1 phase (cyclin D1/pRb), S phase (cyclin E/E2F), G2 phase (cyclin B), and M phase (cyclin A) protein and mRNA at 6 hrs, 24 hrs, and 72 hrs PHx. HGF, TGFα, and TGFβ1 growth factor expressions were also enhanced. We suggest that silymarin plays a crucial role in accelerated liver regeneration after PHx. SN - 1741-427X UR - https://doi.org/10.1155/2015/603529 DO - 10.1155/2015/603529 JF - Evidence-Based Complementary and Alternative Medicine PB - Hindawi Publishing Corporation KW - ER -