Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive)

Table 4

Anticancer activities of Olea europaea.

S. no.	Part/type of extract/compound	Cell line used	Activity	Reference drug	Reference
1	Maslinic acid	HT29 human colon cancer cell line	Dose dependent activity	Hydroxytyrosol	[161]
2	Hydroxytyrosol and hydroxytyrosyl laurate	Human monocytoid cell line	The best	H2O2	[158]
3	Oleanolic acid	Human hepatoma cell line HepG2	Good	—	[157]
4	Methanolic extract of leaves	Human leukemic cell line	High activity	5-Bromodeoxyuridine	[156]
5	Erythrodiol, uvaol, oleanolic acid, and maslinic acid	MCF-7 human breast cancer cell lines	High activity	Trolox	[155]
6	Water and methanolic extracts of olive leaves	Human breast adenocarcinoma (MCF-7), human urinary bladder carcinoma (T-24), and bovine brain capillary endothelial (BBCE)	Good	FGF-2	[154]
7	Aqueous extract of leaves	MKN45 (stomach cancer), MFC7 (breast cancer), NCI-H460 (lung cancer), HCT116 (colon cancer)	Good	MTT	[171]
8	Olive leaf extract	MKN45, HCT116, NCI-H460, and MCF7	Good	—	[171]
9	Erythrodiol	HT-29 human adenocarcinoma cells	Dose dependent activity	Caspase-3	[153]
10	Maslinic acid	HT29 human colon cancer cell line	Dose dependent activity	Hydroxytyrosol	[160]
11	Virgin olive oil phenolics extract	HT115 human colon cancer cells	Dose dependent activity	—	[260]
12	Oleuropein	HeLa human cervical carcinoma cells	Good	—	[261]