Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive)

Table 3

Antidiabetic activities of Olea europaea.

S. no.	Part/type of extract/compound	Disease/assay	Animal model	Effective dose	Reference drug	Reference
1	Olive leaf biophenols (oleuropein + hydroxytyrosol)	Insulin sensitivity improvement	Middle aged overweight men	58.8 mg	—	[151]
2	Aqueous extract of leaves	Antidiabetic assay	Streptozotocin induced diabetic rats	200 mg/Kg	Metformin	[259]
3	Oleanolic acid	Diabetic neuropathy prevention	Sprague Dawley rats	60 mg/Kg	Streptozotocin	[149]
4	Ethanolic extract of leaves	Antidiabetic activity	Male adult Wistar rats	0.5 g/Kg	Glibenclamide	[146]
5	Oleuropein and hydroxytyrosol	Antidiabetic and antioxidant activities	Adult male Wistar rats	16 mg/Kg	Trolox	[145]
6	Oleuropein	Hypoglycemic and antioxidant effect	Male New Zealand rabbits	20 mg/Kg	Alloxan	[143]
7	Oleanolic acid	Antihyperglycemic activity	In vitro	—	Oleuropein	[144]
8	Oleanolic acid demethyl	-Amylase and lipase inhibition	In vitro	—	Oleuropein	[117]