TY - JOUR
A2 - Kim, Cheorl-Ho
AU - Hwang, Yun-Ho
AU - Kim, Kwang-Jin
AU - Kim, Jong-Jin
AU - Kang, Kyung-Yun
AU - Lee, Sung-Ju
AU - Jeong, Gil-Yeon
AU - Choi, Kyung-Hee
AU - Son, Young-Jin
AU - Yee, Sung-Tae
PY - 2015
DA - 2015/02/09
TI - Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice
SP - 373145
VL - 2015
AB - Protective effect of new oriental medicine (Kyungokgo mixed with water extract of Hovenia dulcis, KOGHD) was assessed on the bone loss induced mice by ovariectomy. In the in vivo experiments, antiosteoporosis effect of KOGHD was investigated using ovariectomized osteoporosis mice model. After 6 weeks of treatment, the mice were euthanized, and the effect of Kyungokgo (KOG) and KOGHD on body weight, spleen weigh, thymus weight, uterine weight, serum biochemical indicators, bone weight and length, immune cell population, bone morphometric parameters, and histological stains was observed. Our results showed that KOGHD prevented the deterioration of trabecular microarchitecture caused by ovariectomy, which were accompanied by the lower levels of bone turnover markers and immune cell population as evidenced by the inhibition of RANKL-mediated osteoclast differentiation without cytotoxic effect on bone marrow derived macrophages (BMMs). Therefore, these results suggest that the Hovenia dulcis (HD) supplementation in the KOG may also prevent and treat bone loss.
SN - 1741-427X
UR - https://doi.org/10.1155/2015/373145
DO - 10.1155/2015/373145
JF - Evidence-Based Complementary and Alternative Medicine
PB - Hindawi Publishing Corporation
KW -
ER -