Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins

Figure 5

Effect of triterpene α,β-amyrone on rats paw edema induced by 1% of solution of carrageenan into the intraplantar surface of right hind paw and the effects of α,β-amyrone on mice ear edema induced by a phenol model. (a) α,β-amyrone was administered at concentrations of 5 and 10 mg/kg and the edema was measured at the indicated times. The effect of saline injected in the control group is also shown. (b) α,β-amyrone was administered at concentrations of 0.6, 0.3, and 0.1 mg/kg and dexamethasone of 0.1 mg/kg on mice ear edema induced by a phenol model. Data are expressed as mean ± standard error of five animals per group. The significance was determined using ANOVA and Dunnett’s test ( compared with control group).

(a)

(b)