Olive Leaf Extract Attenuates Obesity in High-Fat Diet-Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis
Effects of OLE on the expression of genes involved in thermogenesis in the epididymal adipose tissue of HFD-fed mice. (a) The expression of genes involved in uncoupled respiration and mitochondrial biogenesis was determined by RT-PCR and normalized to that of GAPDH; (b) protein levels of p-CREB and total CREB were determined by western blotting and normalized to β-actin protein levels. Data represent the results of three independent experiments ( or 3 per experiment); indicates statistical significance. Values are the means ± SEM, for each group.
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