Olive Leaf Extract Attenuates Obesity in High-Fat Diet-Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis
Effects of OLE on body weight gain, food efficiency ratio (FER), and visceral fat-pad weights of HFD-fed mice. Mice were fed CD, HFD, OLD, or SD for 8 weeks. Changes in the (a) body weight, (b) body weight gain, (c) food intake, (d) FER, and (e) visceral fat-pad weights. (f) Histological analysis of the epididymal adipose tissue from each group was conducted to quantify the size of adipocyte. (Left) Representative pictures of hematoxylin-eosin (H&E)-stained fat cells from the mice epididymal adipose tissue (×100). (Right) Densitometric analysis of the average adipocyte diameter in the epididymal adipose tissue of mice. Values are presented as means ± SEM (). Mean values indicated with different letters indicate statistical significance (); FER = Body weight gain for experimental period (g)/food intake for experimental period (g).
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