Mikania glomerata: Phytochemical, Pharmacological, and Neurochemical Study

Table 5

Evaluation of anxiolytic action mechanism of standardized ethanol extract of leaves from M. glomerata in elevated plus-maze test.

Groups ()	NEOA	TTOA (seconds)
Control (12)	11.67 ± 0.5	123.8 ± 0.41
DZP 2 (12)	15.83 ± 0.24^a	207.3 ± 0.70^a
EPMG 200 (12)	11.33 ± 0.38	123.6 ± 0.40
EPMG 300 (12)	11.67 ± 0.75	124.6 ± 0.40
EPMG 400 (12)	17.08 ± 0.78^a,b,c,d	226.3 ± 0.62^a,b,c,d
FLU 2.5 (12)	10.92 ± 0.68	123.5 ± 0.56
FLU 2.5 + DZP 2 (12)	10.58 ± 0.48^b	124.6 ± 0.40^b
FLU 2.5 + EPMG 200 (12)	10.25 ± 0.46	122.8 ± 0.28
FLU 2.5 + EPMG 300 (12)	10.58 ± 0.48	123.6 ± 0.40
FLU 2.5 + EPMG 400 (12)	11.5 ± 0.47^e	123.8 ± 0.55^e

Values represent the mean ± SEM of the number of animals used in experiments. represents the number of animals in each group. compared with negative control, , compared with diazepam group, , compared with group EPMG 200, compared with EPMG 300 group, and , compared with FLU 2.5 + EPMG 400 group (ANOVA and -Student-Newman-Keuls as post hoc test). EPMG: standardized ethanol extract of leaves of M. glomerata; DZP: diazepam; and FLU: flumazenil.