Mikania glomerata: Phytochemical, Pharmacological, and Neurochemical Study

Table 4

Evaluation of anxiolytic action mechanism of standardized ethanol extract of leaves of M. glomerata on motor coordination in rotarod test.

Groups ()	Number of falls	Residence time on the rotating bar (seconds)
Control (12)	1.67 ± 0.14	176.1 ± 1.02
DZP 2 (12)	2.83 ± 0.17^a	167.4 ± 3.18^a
EPMG 200 (12)	1.33 ± 0.31	177.3 ± 0.81
EPMG 300 (12)	1.50 ± 0.19	176.3 ± 0.60
EPMG 400 (12)	2.08 ± 0.47^a	174.1 ± 1.29^a
FLU 2.5 (12)	1.58 ± 0.19	177.5 ± 0.36^b
FLU 2.5 + DZP 2 (12)	1.67 ± 0.31^b	176.5 ± 0.36
FLU 2.5 + EPMG 200 (12)	1.33 ± 0.33	177.8 ± 0.27
FLU 2.5 + EPMG300 (12)	1.58 ± 0.23	177.4 ± 0.47
FLU 2.5 + EPMG400 (12)	1.58 ± 0.26^c	177.7 ± 0.79^c

Values represent the mean ± SEM of the number of animals used in experiments. represents the number of animals in each group. compared with negative control (vehicle), , compared with diazepam group, and , compared with FLU 2.5 + EPMG 400 group (ANOVA and -Student-Newman-Keuls as post hoc test). EPMG: standardized ethanol extract of leaves of M. glomerata; DZP: diazepam; and FLU: flumazenil.