Mikania glomerata: Phytochemical, Pharmacological, and Neurochemical Study

Table 3

Evaluation of anxiolytic action mechanism of standardized ethanol extract of leaves from M. glomerata in light dark box test.

Groups ()	Residence time in the light compartment (seconds)
Control (12)	104.3 ± 0.33
DZP 2 (12)	158.3 ± 0.48^a
EPMG 200 (12)	133.3 ± 0.38^a
EPMG 300 (12)	157.3 ± 0.41^a
EPMG 400 (12)	169.3 ± 0.38^a,b,c,d
FLU 2.5 (12)	107.3 ± 0.38
FLU 2.5 + DZP 2 (12)	102.7 ± 0.38^b
FLU 2.5 + EPMG 200 (12)	102.3 ± 0.38
FLU 2.5 + EPMG300 (12)	104.7 ± 0.51
FLU 2.5 + EPMG400 (12)	108.7 ± 0.62^e

Values represent the mean ± SEM of the number of animals used in experiments. represents the number of animals in each group. compared with vehicle (negative control), , compared with diazepam group, , compared with group EPMG 200, compared with EPMG 300 group, , compared with group EPMG 400 (ANOVA and -Student-Newman-Keuls as post hoc test). EPMG: standardized ethanol extract of leaves of M. glomerata; DZP: diazepam; and FLU: flumazenil.