Mikania glomerata: Phytochemical, Pharmacological, and Neurochemical Study

Table 2

Evaluation of sedative action mechanism of standardized ethanol extract of leaves of M. glomerata in open field test.

Groups ()	Number of crossings	Number of groomings	Number of rearings
Control (12)	98.58 ± 1.19	4.83 ± 0.30	45.33 ± 0.14
DZP 2 (12)	38.58 ± 0.96^a	2.58 ± 0.15^a	13.33 ± 0.14^a
EPMG 200 (12)	94.5 ± 0.15^b	2.42 ± 0.26	41.0 ± 0.25^b
EPMG 300 (12)	95.5 ± 0.15^b	2.58 ± 0.19	46.0 ± 0.25^b
EPMG 400 (12)	103.5 ± 0.15^b	2.75 ± 0.18	47.0 ± 0.25^b
FLU 2.5 (12)	92.5 ± 0.15	4.58 ± 0.31	44.3 ± 0.14
FLU 2.5 + DZP 2 (12)	89.5 ± 0.15^b	4.67 ± 0.39^b	45.33 ± 0.14^b
FLU 2.5 + EPMG 200 (12)	94.5 ± 0.15	2.58 ± 0.29	45.5 ± 0.55
FLU 2.5 + EPMG 300 (12)	97.5 ± 0.15	2.67 ± 0.26	46.67 ± 0.67
FLU 2.5 + EPMG 400 (12)	103.5 ± 0.15	2.75 ± 0.22	47.5 ± 0.78

Values represent the mean ± SEM of number of animals used in experiments. represents the number of animals in each group. , compared with negative control (vehicle), , compared with diazepam group (ANOVA and -Student-Newman-Keuls as post hoc test). EPMG: standardized ethanol extract of leaves of M. glomerata; DZP: diazepam; and FLU: flumazenil.