Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints
Table 1
Inclusion, exclusion, and stratification criteria for the identification of the literature for the evaluation of the efficacy and safety of Cimicifuga racemosa.
Efficacy
General safety
Safety in estrogen-sensitive organs
Liver safety
Inclusion criteria
(1) Medical application of Black Cohosh
+
+
+
+
(2) 3-month treatment period at a minimum
+
(3) Full publication of clinical studies
+
+
+
+
(4) Efficacy in natural climacteric complaints (neurovegetative, psychic)
+
(5) Occurrence and frequency of adverse events
+
+
+
(6) Influence on hormone parameters, breast, and uterus
+
(7) Influence on liver function parameters
+
Exclusion criteria
(1) Preparations containing more than two ingredients