Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test: Involvement of Peripheral β-Adrenoceptors
Figure 4
Graphs illustrating the antinociceptive effect of preinjection of the PNMT inhibitor, DCMB, prior to DBV treatment on the formalin test. DBV (Veh + DBV + F) significantly decreased pain behaviors compared to the vehicle group (Veh + Veh + F, **). DCMB-injected groups that were injected with vehicle [DCMB (3, 10 mg) + Veh + F] did not change formalin-induced pain responses during the early and late phases. While a low dose of DCMB given prior to DBV treatment [DCMB (3 mg) + DBV + F] did not change formalin-induced pain responses, a higher dose of DCMB given prior to DBV treatment [DCMB (10 mg) + DBV + F] significantly suppressed formalin-induced pain behaviors during the late phase of the formalin test as compared to that of the DBV-treated group (#).
