Chimonanthus nitens var. salicifolius Aqueous Extract Protects against 5-Fluorouracil Induced Gastrointestinal Mucositis in a Mouse Model

Figure 6

Changes of cell apoptosis and proliferation in mice small intestine. To determine the expression of apoptosis and proliferation relevant genes, expressions of caspase-3 (a), PCNA (b), and cyclin-D1 (c) were quantified by real-time PCR. Moreover, small intestine sections were prepared for immunohistochemical staining of PCNA (d) and quantified for the immunohistochemical density of PCNA positive cells (e). Each bar represents the mean ± SEM (𝑛=8/group); ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.005.

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